Sách Spectrophotometric Determination of Allopurinol in Tablet Formulation

Allopurinol (1H-pyrazolo[3,4-d]pyrimidin-4-ol) (Fig. 1) is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with leukaemia, radiotherapy, antineoplastic agents and treatment with diureticsconditions.1 Allopurinol is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and acts to inhibit xanthine oxidase. In the presence of xanthine oxidase, allopurinol will be converted to alloxanthine (Fig. 2), after that the formation of uric acid from xanthine and hypoxanthine will be inhibited.