Sách Resveratrol Derivatives from Stem Bark of Hopea and Their Biological Activity Test

Hopea is one of the main genus of Dipterocarpaceae, consisting of approximately 100 species and widely distributed in Indonesia specially in Kalimantan1,2 and until now only few species have been investigated. This family of plant is known to produce a variety of resveratrol oligomers.3–18 These structures are very interesting and showed interesting biological activity, such as antibacterial, anticancer, antihepatotoxic and anti-HIV.3–18 Thus Dipterocarpaceae plants are very promising for chemical research in natural product and pharmaceutical industry. In our continuing phytochemical study of the Dipterocarpaceae family occuring in Indonesia, we have examined resveratrol oligomer constituents from some species of Hopea odorata, H. mengarawan and H. nigra. Hopea is widely distributed in tropical rain forest of Sumatra, Malaysia and up to the Andaman islands, and it is locally known as merawan hitam or pengarawan3 This paper reports first investigation of seven resveratrol derivatives from the stem bark of these species. The structures of these compounds were derived based on the analysis of the UV, IR, MS and NMR, including 1D and 2D NMR (1H- 1H COSY, HMQC, HMBC and NOESY) spectra.