Tài liệu Melanoma in the clinic – diagnosis, management and complications of malignancy Edited by Mandi Murph

MELANOMA IN THE CLINIC – DIAGNOSIS, MANAGEMENT AND COMPLICATIONS OF MALIGNANCY
Edited by Mandi Murph

Contents
Preface IX


Part 1 Melanoma Models and Diagnostic Techniques 1
Chapter 1 Acral Melanoma: Clinical, Biologic
and Molecular Genetic Characteristics 3
Minoru Takata
Chapter 2 Histopathological Diagnosis of
Early Stage of Malignant Melanoma 15
Eiichi Arai, Lin Jin, Koji Nagata and Michio Shimizu
Chapter 3 Wnt/β-Catenin Signaling Pathway in
Canine Skin Melanoma and a Possibility
as a Cancer Model for Human Skin Melanoma 23
Jae-Ik Han and Ki-Jeong Na
Chapter 4 Improving Diagnosis by Using Computerized Citometry 41
Valcinir Bedin
Chapter 5 Modern Techniques for
Computer-Aided Melanoma Diagnosis 63
Maciej Ogorzałek, Leszek Nowak,
Grzegorz Surówka and Ana Alekseenko
Chapter 6 Investigation of
Relations Between Skin Cancer Lesions‘
Images and Their Reflectance and Fluorescent Spectra 87
Petya Pavlova, Ekaterina Borisova, Lachezar Avramov,
Elmira Petkova and Petranka Troyanova


Part 2 Immunology and
the Association with Melanoma 105
Chapter 7 Co-operation of Innate and
Acquired Immunity for Controlling Tumor Cells 107
Hidemi Takahashi
VI Contents
Chapter 8 Adoptive T-Cell Therapy
of Melanoma: Promises and Challenges 115
Patrick Schmidt and Hinrich Abken
Chapter 9 Current Perspectives on
Immunomodulation of NK Cells in Melanoma 133
Tadepally Lakshmikanth and Maria H. Johansson
Chapter 10 Tumour-Associated Macrophages (TAMs)
and Cox-2 Expression in Canine Melanocytic Lesions 163
Isabel Pires, Justina Prada, LuisCoelho,
Anabela Garcia and Felisbina Luisa Queiroga


Part 3 Disease Management and Clinical Cases 181
Chapter 11 Surgical Management of
Malignant Melanoma of Gastrointestinal Tract 183
Thawatchai Akaraviputh and Atthaphorn Trakarnsanga
Chapter 12 Surgical Treatment of Pulmonary
Metastases from Melanoma: Emerging Options 201
Pier Luigi Filosso, Alberto Sandri, Enrico Ruffini, Paolo Olivo Lausi,
Maria Cristina Bruna and Alberto Oliaro
Chapter 13 Melanoma-Predisposing CDKN2A Mutations
in Association with Breast Cancer:
A Case-Study and Review of the Literature 211
Klára Balogh, Edina Nemes, Gabriella Uhercsák, Zsuzsanna Kahán,
György Lázár, Gyula Farkas, Hilda Polyánka, Erika Kiss, Rolland
Gyulai, Erika Varga, Erika Keresztné Határvölgyi, László Kaizer,
Lajos Haracska, László Tiszlavicz, Lajos Kemény,
Judit Oláh and Márta Széll
Chapter 14 The Biology and Clinical Relevance
of Sentinel Lymph Nodes in Melanoma 225
Brian Parrett, Lilly Fadaki, Jennifer Y. Rhee and Stanley P.L. Leong


Part 4 Melanoma Complications and Rare Types of Disease 239
Chapter 15 Melanoma and Pregnancy 241
C. Pagès and M. Viguier
Chapter 16 Malignant Melanoma in Genito-Urinary Tract 265
Abdulkadir Tepeler, Mehmet Remzi Erdem, Sinasi Yavuz Onol,
Abdullah Armagan and Alpaslan Akbas
Chapter 17 The Stage of Melanogenesis in Amelanotic Melanoma 277
Naoki Oiso and Akira Kawada
Contents VII
Chapter 18 The Interaction Between
Melanoma and Psychiatric Disorder 287
Steve Kisely, David Lawrence, Gill Kelly,
Joanne Pais and Elizabeth Crowe


Preface
Melanoma Oncologists who have in the past struggled with resolving how best to treat
their patients given the few effective therapeutics available are now beginning to confront
the disease directly. These new tools are likely to change clinical practice surrounding
melanoma.
In the first section of this book, several manuscripts discuss imaging techniques for diagnosis
– currently the best way to cure melanoma early before it develops into a late ‐
stage, metastatic disease. Further, this book discusses the clinical aspects of melanoma
treatment in surgery and long‐term management. Acral, cutaneous and mucosal melanomas
are represented in this book, along with some rather unusual clinical observations.
As such, it provides insight into rare case studies only observed by a few clinicians.
When most people consider melanoma, it is likely to be regarded as cutaneous
melanoma derived by overexposure to a lifetime of UV radiation. In contrast, manuscripts
presented here discuss melanoma in the gastrointestinal tract, genito‐urinary
tract, female genital tract, pulmonary metastases, familial mutations leading to melanoma,
canine melanoma and melanoma in pregnancy. It is a fascinating representation
of the diversity of clinical cases that exist globally.
Again, I have to thank several outstanding people, without whom this would not have
otherwise been possible – Ana Pantar, Petra Nenadic, Juliet Eneh and Molly Altman.
These people helped me throughout this process. In addition, I would also like to thank
my loving spouse, Gary Rollie, who is always a supportive champion of my career. This
past year he listened to me say that, “This will only take a few more minutes,” knowing
that it wasn’t true, but understanding that at some point I would finish. And I did.
I hope you enjoy reading this book as much as I did.
Sincerely,
Mandi Murph, Ph.D.
Assistant Professor
Department of Pharmaceutical and Biomedical Sciences
University of Georgia
College of Pharmacy
Athens, GA, USA