Tài liệu Medical complications of type 2 diabetes Edited by Colleen Croniger

MEDICAL COMPLICATIONS OF TYPE 2 DIABETES
Edited by Colleen Croniger

Contents
Preface IX


Part 1 Insulin Resistance 1
Chapter 1 Insulin Secretion and Actions 3
Sarawut Jitrapakdee and Briony E. Forbes
Chapter 2 The Oral Glucose Tolerance Test:
An Old but Irreplaceable Test to Evaluate
Glucose Metabolism and Cardiovascular Risk 27
Gian Paolo Fra, Ettore Bartoli and
Gian Piero Carnevale Schianca
Chapter 3 The Role of Parathyroid
Hormone-Related Protein (PTHRP)
in the Pathophysiology of Diabetes Mellitus 39
Ioannis Legakis
Chapter 4 Impaired Vascular BK
Channel Function in Type 2 Diabetes Mellitus 53
Tong Lu and Hon-Chi Lee


Part 2 Endothelial Cells and Type 2 Diabetes 71
Chapter 5 Endothelial Progenitor Cell Dysfunction in
Diabetes Mellitus Type-2: Focus on Nitric Oxide System 73
Saher Hamed
Chapter 6 Glycaemic Control and Protection
of the Vasculature from Glucose Toxicity 87
Hong Ding and Chris R. Triggle
Chapter 7 Endothelial Dysfunction and
Therapeutic Intervention in Type 2 Diabetes 111
Fernando Grover Páez


Part 3 Genetics of Type 2 Diabetes 143
Chapter 8 Using Gene Expression Signatures
to Dissect Insulin Resistance Subtypes 145
Brad Hayward, Nicky Konstantopoulos and Ken R. Walder
Chapter 9 The Role of Single Nucleotide Polymorphisms of
Untranslated Regions (Utrs) in Insulin Resistance
Pathogenesis in Patients with Type 2 Diabetes 165
Małgorzata Małodobra
Chapter 10 Genetics of Endothelial Damage
Associated to Diabetes Mellitus Type 2 189
Lorena García, Carlos Wolff, Verónica Araya,
Gloria López, Sergio Lobos, Pilar Durruty and
Daniela Seelenfreund
Chapter 11 Functional Context Network of T2DM 213
Anja Thormann and Axel Rasche


Part 4 Complications of Type 2 Diabetes 231
Chapter 12 Sarcopenia, Sarcopenic Obesity and Insulin Resistance 233
John A. Batsis and Silvio Buscemi
Chapter 13 Type 2 Diabetes and
Pancreatic Cancer – A Possible Reason 257
Parviz M Pour
Chapter 14 Pathophysiology in Type 2 Diabetes –
Type 2 Diabetes and Sleep-Disordered
Breathing/Sleep Apnea – Role of Adipocytokines 267
Ken Kishida


Part 5 Treatments and Therapy 277
Chapter 15 Can Bariatric or Metabolic
Surgery Cure Type 2 Diabetes? 279
Gustavo P. S. Miguel, Perseu Carvalho,
João Luiz Azevedo, Murilo Hosken Júnior,
Évelyn Zambrana, Otávio Azevedo and Isaac Abreu
Chapter 16 Nuclear Imaging of Glucose Transport/Metabolism –
An Interesting Tool to Screen Insulin Resistance,
Refine Diagnosis of Type 2 Diabetes, Understand
Disease Mechanisms, and/or Evaluate New Therapies 291
P. Perret, M. Henri, L. Slimani,
D.Fagret and C. Ghezzi
Contents VII
Chapter 17 Targeting PKA Signaling to
Prevent Metabolic Syndrome and Delay Aging 303
Linda C Enns and Warren C Ladiges
Chapter 18 Targeting AMPK for
Therapeutic Intervention in Type 2 Diabetes 321
Mohamed Kodiha and Ursula Stochaj
Chapter 19 Design and Evaluation of a Complex
Phytoceutical Formulation for Circulatory Diseases 349
J. Olalde, A. Antoshechkin, O. del Castillo,
R. Guzmán and F. Améndola
Chapter 20 Effectiveness of Fenugreek for Lowering
Hemoglobin (HbA1c) in Patients with Self-Management
of Type 2 Diabetes: A Randomized Controlled Trial 393
Rashid Ansari and Saiqaa Ansari

Preface
Obesity and type 2 diabetes are increasing worldwide problems. In this book we
reviewed insulin secretion in both healthy individuals and in patients with type 2
diabetes. Because of the risk associated with progression from insulin resistance to
diabetes and cardiovascular complications increases along a continuum, we included
several chapters on the damage of endothelial cells in type 2 diabetes and genetic
influences on endothelial cell dysfunction. Cardiovascular complications occur at a
much lower glucose levels, thus a review on the oral glucose tolerance test compared
to other methods was included. The medical conditions associated with type 2
diabetes such as pancreatic cancer, sarcopenia and sleep disordered breathing with
diabetes were also discussed. The book concludes with several chapters on the
treatments for this disease offering us hope in prevention and successful alleviation of
the co-morbidities associated with obesity and type 2 diabetes.
Colleen Croniger
Department of Nutrition, Case Western Reserve University,
School of Medicine, Cleveland,Ohio
US