Tài liệu Gene therapy - developments and future perspectives - Edited by Chunsheng Kang

GENE THERAPY - DEVELOPMENTS AND FUTURE PERSPECTIVES
Edited by Chunsheng Kang

Contents
Preface IX
Part 1 Approach of Gene Therapy 1
Chapter 1 New Vectors for Stable and Safe Gene Modification 3
Francisco Martín, Karim Benabdellah, Marién Cobo,
Pilar Muñoz, Per Anderson and Miguel G. Toscano
Chapter 2 Gene Therapy Using RNAi 31
Yu-Lin Yang, Wen-Teng Chang and Yuan-Wei Shih
Chapter 3 Scalable Technology to Produce
Pharmaceutical Grade Plasmid DNA for Gene Therapy 53
Odalys Ruiz Hernández, Miladys Limonta Fernández, Jorge Valdes
Hernández, Martha Pupo Peña and Eduardo Martínez Díaz
Chapter 4 Small Interfering RNAs:
Heralding a New Era in Gene Therapy 71
Maro Bujak, Ivana Ratkaj, Mirela Baus Loncar,
Radan Spaventi and Sandra Kraljevic Pavelic
Chapter 5 MicroRNAs in Disease and Health:
Diagnostic and Therapeutic Potentials 93
Mohammad Reza Noori-Daloii and Azim Nejatizadeh
Chapter 6 Gene Therapy Strategies
Incorporating Large Transgenes 121
Jennifer Johnston, Christopher B. Doering and H. Trent Spencer


Part 2 Evaluation of Gene Therapy 143
Chapter 7 Recent Advances and
Improvements in the Biosafety of Gene Therapy 145
Jaichandran Sivalingam and Oi Lian Kon
Chapter 8 Impacts of DNA Microarray
Technology in Gene Therapy 189
Yadollah Omidi, Amir Ata Saei and Jaleh Barar
Chapter 9 Hopes and Disillusions in Therapeutic
Targeting of Intercellular Communication in Cancer 217
Mustapha Kandouz
Chapter 10 Promising Role of
Engineered Gene Circuits in Gene Therapy 233
Wei-dong Wang and Jinyi Lang
Chapter 11 Comparison of DNA Delivery and
Expression Using Frequently Used Delivery Methods 247
Sara A. Collins, David Morrissey, Simon Rajendran,
Garrett Casey, Martina F. Scallan, Patrick T. Harrison,
Gerald C. O’Sullivan and Mark Tangney


Part 3 Potential Applications of Gene Therapy in Future 265
Chapter 12 Preclinical and Clinical Aspects
of Gene Therapy in Myocardial Infarction 267
Saurabh Bharti, Ashok Kumar Sharma,
Bhaskar Krishnamurthy and Dharamvir Singh Arya
Chapter 13 Gene Therapy for Therapeutic Angiogenesis 289
Rudolf Kirchmair
Chapter 14 Cancer Gene Therapy -
Developments and Future Perspectives 299
David A Good, Wei Duan, Jozef Anné and Ming Q Wei
Chapter 15 Differential Gene Expression
and Its Possible Therapeutic Implications 315
Safdar Ali and Sher Ali
Chapter 16 Engineered Drug Resistant
Cell-Mediated Immunotherapy 335
Anindya Dasgupta and H. Trent Spencer



Preface
We are delighted to be offered the opportunity to help construct a book dealing with
important issues of development and future perspectives in gene therapy.
The goal of our work on this project is to provide a means, via the contributions of
many collaborating authors, to make our doctors become comfortable with the common
problems of gene therapy in a single accessible book.
The current volume aims at providing an up-to-date report on the field of the development
and future perspectives in gene therapy. Contributions consist of basic and
translational research, as well as clinical experiences, and they outline functional
mechanisms, predictive approaches, patient-related studies, and upcoming challenges
in this stimulating but also controversial field of gene therapy research.
We hope that our efforts and those of our collaborators will well present our specialty
and may, perhaps, inspire others to delve a bit more deeply into a topic of interest.
Dr. Chunsheng Kang
Professor at Lab of Neuro-oncology
Tianjin Neurological Institute
China