Tài liệu Gastric carcinoma ‐ molecular aspects and current advances

GASTRIC CARCINOMA ‐ MOLECULAR ASPECTS AND CURRENT ADVANCES
Edited by Mahmoud Lotfy

Contents
Preface IX


Part 1 Molecular and Cellular Biology 1
Chapter 1 Oncogenic Signaling in Gastric Cancer 3
Natália R. Costa, Andreia Sousa, Cristina Teixeira,
Joana Castro, Nuno Guimarães and Filipe Santos–Silva
Chapter 2 Genetic Instability in Gastric Cancer 27
Petra Hudler, Matjaz Vogelsang and Radovan Komel
Chapter 3 The Epigenetic Aspect of Gastric Cancer 55
Xian Wang and Hongchuan Jin
Chapter 4 Molecular Features and Their Clinical
Implications on Gastric Adenocarcinoma 71
Yves Dittmar and Utz Settmacher
Chapter 5 miRNAs in Gastric Cancer 87
Yu-Lun Liao, Kuo-Wang Tsai and Wen-chang Lin
Chapter 6 Integrin and E-Cadherin Expression
Alterationsas a Possible Reason
of Undifferentiated-TypeGastric
Carcinoma Diversity 105
Natalia Yanchenko and Hiroyuki Sugihara
Chapter 7 Exploring the Utility of Carbohydrate
Associated Transferase Activities as Potential
Tumor Markers for Human Gastric Cancer 123
E.V. Chandrasekaran and Khushi L. Matta
Chapter 8 Human Epidermal Growth Factor
Receptor Family (HER) in Gastric Cancer 141
Jolanta Czyzewska
Chapter 9 Free Radicals and Gastric Cancer 159
Mahmoud Lotfy and Yousery E. Sherif

Part 2 Immunology and Immunohistomorphology 185
Chapter 10 Immune Cell Responses in Gastric Carcinoma:
An Analysis Based on Histopathology 187
Haruo Ohtani
Chapter 11 Immunohistochemical Profile of
Mucins in Gastric Carcinoma 201
Daniela Lazăr, Sorina Tăban and Sorin Ursoniu

Part 3 Microbial Infections and Their Implications 237
Chapter 12 Genetic Factors Involved in the Genesis
of Helicobacter Pylori-Induced Gastric Cancer 239
Asahi Hishida
Chapter 13 A Double-Edged Sword: Roles of
Helicobacter Pylori in Gastric Carcinoma 265
Li-Jun Xue , Quan-Sheng Su, Xiao-Bei Mao,
Qing Lin, Xiao-Bei Liu, Chang Liu, Yong Lin,
Ji-Hong Yang, Hong-Ju Yu and Xiao-Yuan Chu

Part 4 Current and Future Treatment 295
Chapter 14 Gastric Carcinoma Neoadjuvant
and Adjuvant Therapy 297
Yüksel Ürün, Ali Ayberk Beşen and Hüseyin Abalı
Chapter 15 Establishment of the Standard Prophylactic
Strategy for Peritoneal Recurrence and
Proposal of the Optimal Therapeutic
Protocol for Gastric Cancer 313
Shimada S, Kuramoto M, Ikeshima S, Matsuo A,
Ikuta Y, Kuhara H and Baba H
Chapter 16 Hepatic Metastases from Gastric Carcinoma 329
Guido Alberto Massimo Tiberio, Nazario Portolani
and Stefano Maria Giulini
Chapter 17 Perspectives in the Treatment
of Incurable Gastric Cancer 339
Yves Dittmar and Utz Settmacher

Preface
Gastric cancer is one of the most common tumors worldwide. It has a heterogeneous
milieu with alteration of many genes, gene products, along with gene polymorphisms.
Further, the tumor immunology, oxidative stress, and microbial infections such as
Helicobacter pylori and Epstein‐Barr hold a vital link to gastric tumorigenesis. These
diverse factors are playing a key role and have a direct impact on the prognosis of the
gastric cancer and the survival of gastric cancer patients. In spite of the great advances
of science, medicine and modern technology, the trend of gastric cancer in the last
decades is directed toward the stability for many areas and decreasing in some other
parts of world. The thankful enterprise to open more novel windows for the
development of innovative therapeutic strategies against gastric cancer is greatly
appreciated for scientists all over the world. This book is appropriate for scientists and
students in the field of oncology, gastroenterology, molecular biology, immunology,
cell biology, biology, biochemistry, pathology, and many other fields ‐ this
authoritative text carefully explains the fundamentals, providing a general overview
of the principles followed by more detailed explanations of these recent topics
efficiently. With its easy‐to‐read writing style, this book introduces in‐depth coverage
on such hot topics as signaling pathways, H. pylori, epigenetic and oncogenic
background of gastric cancer, and recent treatment modalities. The authors are a
sincere and diverse team of scientists who firmly contributed in that field. The topics
presented herein contain the most recent knowledge in gastric cancer concerning the
oncogenic signaling, genetic instability, the epigenetic aspect, molecular features and
their clinical implications, miRNAs, integrin and E‐cadherin, carbohydrate‐associatedtransferases,
free radicals, immune cell responses, mucins, Helicobacter‐pylori,
neoadjuvant and adjuvant therapy, prophylactic strategy for peritoneal recurrence,
and hepatic metastasis.
Our authentic gratitude is due to our brilliant authors, co‐authors, reviewers,
secretaries, and the publisher with his sincere team, especially Mr. Vidic. Finally, I
would like to convey my faithful appreciation for the families of this wonderful
team for their patient, support and encouragement. This book is dedicated
faithfully to the devoted families of the authors and the amazing family of the
editor, the wife, the kids (Nada, Nadeem and Nour) who all ultimately made this
book possible.
Mahmoud Lotfy
Associate Professor of Molecular Cell Biology & Immunology,
Molecular and Cellular Biology Department,
Genetic Engineering and Biotechnology Research Institute,
Minufiya University, Sadat City, Minufiya, Egypt
& Department of Applied Medical Sciences,
Jouf University,
Saudi Arabia