Sách Cancer Biology

Preface xi

Dedication xiii

Acknowledgements xiv

Basic science, terminology and abbreviations xvii

1. What is cancer? 1

2. Natural history: the life of a cancer 9

3. Pathology: defining a neoplasm 32

4. Epidemiology: identifying causes for human cancers 40

5. Oncogenes, tumour suppressor genes and viruses 62

6. Chemical and radiation carcinogenesis 88

7. Mutations, DNA repair and genetic instability 112

8. Familial cancers 128

9. Growth: a balance of cell proliferation, death and differentiation 139

10. Responding to the environment: growth regulation and signal

transduction 168

11. Invasion and metastasis 209

12. Principles of cancer treatment 230

13. Approaches to cancer prevention 263

Appendix: Features of selected cancers 270

Glossary 283

Index 288