Tài liệu Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic res

Hepatitis C virus (HCV) infection is a major cause of liver diseases and liver cancer (1-3).Among the six genotypes of HCV, the most common geno-types of HCV in the United States are genotype 1 (approximately 75%), genotype 2 (15%), and geno-type 3 (7%) (2-5). At present, the standard treatment for chronic HCV genotype 1 infection is 48 weeks with a combination of pegylated (long-acting) inter-feron alfa-2a or alfa-2b plus ribavirin. Outcomes are measured by sustained viral response (SVR), defined as an undetectable viral load 24 weeks after the end of therapy. HCV genotype 1 has been reported to have a 54-56% SVR (2, 6-9).Prior studies have shown better response rates with genotype 2 or 3 with a 24 week-course of therapy (2, 8,9).