Tài liệu Báo cáo y học: "The Diels-Alder-Reaction with inverse-Electron-Demand, a very efficient versatile Cl

Due to small molecular weight traditional chemotherapeutics reach the DNA target by diffusion. But the lack of specificity necessitates highly application doses and results in adverse reactions which hampers the therapeutic outcome. Modern high specific drug formulations, consisting of DNA and derivatives, could circumvent these insurmountable obstacles; unfortunately their physico-chemical properties as well as in the big molecular weight result in a barely noticeable diffusibility, insufficient for therapeutic local concentrations or for an intravital diagnostics imaging. Both approaches need a proper coupling of drugs or intravital contrast agents to carrier molecules for the passage across cellular membranes and subsequently for the transport into subcellular components like the cell nucleus for imaging of molecular processes at the transcriptional level.