Tài liệu Báo cáo y học: "Relationships between free radical levels during carotid endarterectomy and markers

In previous studies we have described a technique to analyze the production of free radicals during carotid endarterectomy based on determination of radical production in vitro in venous blood samples [1,2]. The rationale behind this in vitro technique is that radical production continues in regional venous blood draining a previously ischaemic area due to e.g. activated leucocytes or ongoing lipid peroxidation. Pretreatment of the patients with a xanthine oxidase inhibitor influences radical production, indicating that oxidation of accumulated hypoxanthine has a role to play in this process. The radical production is influenced by several clinical parameters, e.g. occurrence of contralateral stenosis, indicating that it is associated with the severity of the arteriosclerotic disease. There are several markers for the tissue damage characterising the lesion progression in arteriosclerosis, e.g. MMP-9, ICAM-1, MCP-1 and oxLDL.