Tài liệu Báo cáo y học: " Preparation of RGD-modified Long Circulating Liposome Loading Matrine, and its in v

Matrine, the major active component of the traditional Chinese medicine Sophora flavescens, has been used to treat jaundice, reduce liver enzyme activity, prevent hepatic fibrosis (1,2). In recent years, studies have indicated that matrine also inhibits tumor cell proliferation (3), and induces cellular differentiation (4) and apoptosis (5). Our previous study showed that matrine could inhibit proliferation and induce apoptosis in human malignant melanoma A375 cells in a dose-dependent manner. Furthermore, it effectively suppressed their adhesion and invasiveness in vitro (6). However, like most low molecular weight drugs, matrine is able to freely traverse in and out of blood vessels to distribute to nontumor tissues, resulting in accumulation in the liver, spleen or kidneys, diminishing its effects on cancer cells.