Tài liệu Báo cáo y học: "Platinum Agent-Induced Hypersensitivity Reactions: Data Mining of the Public Version

The treatment of metastatic colorectal cancer has progressed significantly over the past 20 years, and currently the FOLFIRI or FOLFOX regimen [1-4], with or without a targeted monoclonal antibody, is the standard treatment [5-8], consisting of the injection of a bolus of 5-fluorouracil (5-FU), irinotecan or oxali- platin (L-OHP), and the infusion of 5-FU/leucovorin, respectively. Future improvements will likely require the incorporation of or substitution with a novel anticancer drug, personalization based on genetic profiling, or pharmacokinetically-guided administration.