Tài liệu Báo cáo y học: "Parvovirus B19 Genotype Specific Amino Acid Substitution in NS1 Reduces the Protein’

Human parvovirus B19 is a ubiquitous infectious agent known to cause erythema infectiosum in children, bone marrow suppression and chronic anemia in susceptible individuals, and fetal hydrops and death in intrauterine infections (2, 25). Studies have also linked the virus to numerous idiopathic conditions such as systemic lupus erythematosus (SLE)-like syndromes, rheumatoid-like arthritis, and liver and kidney disease (10, 27, 37, 40). such phenomena: an immune mediated attack of end-organ antigens due to B19-induced molecular mimicry (22, 43), or direct B19-mediated cellular damage in the absence of viral particle replication (43). Evidence for both mechanisms exists and it is possible that both have a role to play in the diverse clinical picture of B19 disease. The B19 linear, single-stranded DNA genome encodes three major viral proteins; two structural capsid proteins (VP1 and VP2) and three non-structural proteins (the major 77 kDa NS1 and the