Tài liệu Báo cáo y học: "Ozone Therapy and Hyperbaric Oxygen Treatment in Lung Injury in Septic Rats"

In spite of the advanced antibiotic therapies, supportive treatments and technological facilities, sepsis continues to be a clinical entity with high morbidity and mortality [1]. The pathophysiology of sepsis involves complex interactions between host organs and the invading pathogen. Ultimately, tissue damage and organ failure result from the adverse effects of systemic activation of regulatory pathways [2-3]. Systemic elevations in the levels of proinflammatory cytokines such as tumor necrosis factor (TNF-α) and several interleukins (i.e., IL-1, IL-6 and IL-10) play a chief role within this phenomenon [4]. The lung is the organ which is affected initially, and sepsis leads to severe injury in lung tissue [5]. It has been shown that pericytes in lung tissue produce proinflammatory cytokines in response to lipopolysaccharide (LPS) [6].