Tài liệu Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) (1). It has the potential to be involved in the pathogenesis of many CNS diseases either due to excessive release, reduced uptake or alteration of receptor function (2). Neuronal excitotoxicity usually refers to injury and death of neurons arising from prolonged exposure to glutamate and associated excessive influx of ions into the cell. The resulting calcium overload is particularly neurotoxic, leading to the activation of enzymes that degrade proteins, membranes and nucleic acids (3).