Tài liệu Báo cáo y học: "Monoclonal Antibodies against Nucleophosmin Mutants: Potentials for the Detection of

Nucleophosmin (NPM1) is an ubiquitously expressed nucleo-cytoplasmic shuttling protein with prominent nucleolar localization [1, 2]. Previous studies have demonstrated that mutations of the NPM1 gene leading to aberrant cytoplasmic NPM1 expression (NPMc+) occur in about one-third of acute myeloid leukemias (AML) and 45% to 64% of AML with normal karyotype cases [3, 4]. The most common molecular variant of the NPM1 gene is mutation A, accounting for about 75-85% of cases. It is due to a duplication of TCTG tetranucleotide at the C-terminus of the NPM1 gene, which generates a nuclear export signal (NES) motif responsible for cytoplasmic accumulation of NPM1 [5-7].