Tài liệu Báo cáo y học: "Lack of Preemptive Analgesia by Intravenous Flurbiprofen in Thyroid Gland Surgery: A

Preemptive analgesia is the administration of an analgesic before a painful stimulus that prevents the establishment of the altered processing of afferentinput, which amplifies postoperative pain; and effective preemptive analgesia should prevent the estab-lishment of central sensitization caused by incisional and inflammatory injuries (covers the period of surgery and the initial postoperative period).1 Experimental evidences suggest that better postoperative analgesia in patients receiving the analgesic preoperatively compared to those patients, who were treated postoperatively.2-4 Except postoperative pain, perioperative analgesic consumption may be another index of preemptive analgesia, because it can indicate pe-ripheral and central sensitization during surgery in-directly and it has a direct effect on postoperative pain. Unfortunately, perioperative analgesic consumption was ignored in preemptive analgesia re-search. Maybe, that is one of the reasons that some preemptive analgesia research reached negative findings.