Tài liệu Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients

Tacrolimus, a calcineurin inhibitor, remains the of the maintenance treatment scheme inrenal transplant recipients. Both its narrow therapeutic index and its highly pharmacokinetic variance may lead to overtreatment and toxicity or insufficient treatment and transplant rejection, conditions that areusually seen in clinical practice. Thus, it is obvious that the optimal tacrolimus dose has to be achieved soon after transplantation and must be preserved thereafter. In the recent years, effort has been made to de-termine the potential causes of inter- and intra-individual variability. Except for the characteristics of each individual and several environmental