Tài liệu Báo cáo y học: "Evaluation of the Prevalence of Concomitant Idiopathic Cyclic Edema and Cellulit"

Cellulite is a common complex cosmetic problem for many post-adolescent women characterized by relief alterations of the skin surface, which give the skin an orange-peel appearance 1. It has been demonstrated that the angiotensin I-converting enzyme (ACE) and hypoxia-inducible factor-1 alpha (HIF1A) genes play an independent role in predisposing to cellulite. This may provide novel information on the pathophysiology of this common cosmetic problem and offer a research topic for novel beautification interventions 2. Glycosaminoglycans (GAGs) have hydrophilic properties, which lead to excessive fluid retention in the dermis, adipocytes, and interlobular septae. Edema can also lead to vascular compression, hypoxia, and capillary neoformation, resulting in mi-crohemorrhages that are noted upon histologic evaluation