Tài liệu Báo cáo y học: "Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functio

“Old fashioned” drugs are highly active, but their lack of specificity and sensitivity needs high doses of application correlating with adverse reactions. The differentiation between tumorigenic and the surrounding healthy tissue is hardly possible. Whereas old drugs enter the cells by diffusion, the transfer of nucleic acid drugs across cell membrane is very poor and insufficient. Modern drugs and diagnostics overcome the mentioned handicaps. Therefore a carrier system is indispensable for facilitating the transport of nucleic acid based drugs and imaging and therapy components across the cell membrane. Considerations for the improved membrane transport resulted in a series of procedures. The question re-specting the low stability of nucleic acids in biological systems led to the development of numerous DNA analogues possessing higher stability.