Tài liệu Báo cáo y học: "Emulsified Isoflurane Preconditioning Reduces Lung Injury Induced By Hepatic Ischemi

Ischemia/reperfusion (IR) injury represents a complex series of events, including release of reactive oxygen species, nitric oxide imbalance, cytokine cascades, neutrophil accumulation and cell death, re-sulting in cellular and tissue damage1. Hepatic I/R injury, which can been seen in various clinical settings such as liver transplantation, hepatectomy, and hemorrhagic shock, may lead to local and remote organ damage2, yet the precise pathogenesis is not fully de-fined. Massive accumulation of neutrophils in the lung, the development of interstitial pulmonary ede-ma and increased expression of proinflammatory mediators are major features of lung injury induced by hepatic I/R.