Tài liệu Báo cáo y học: "Effect of corticosteroids on phlebitis induced by intravenous infusion of antineopla

Chemotherapy, including novel antineoplastic agents, is becoming increasingly effective for cancer and is performed widely, but adverse drug reactions are still a critical problem. The completion of chemotherapy regimens is an important factor that determines the prognosis of patients, but it is often the case that treatment is discontinued due to adverse drug reactions. Among such reactions, phlebitis induced by intravenous infusion of antineoplastic agents reduces the completion of chemotherapy. The causative factors of phlebitis include the pH and osmotic pressure of the solution, the size of the vein used, the size and material of the catheter, and the infusion periods [1]. A number of methods for avoiding phlebitis have been reported [2, 3], but none are completely effective. Thus, there is an urgent need to develop new methods to prevent and alleviate phlebitis. We already showed that rapid infusion and dilution of VNR are effective for reducing phlebitis [4]. In this study, we investigated other practical methods for preventing phlebitis.