Tài liệu Báo cáo y học: "Effect of 1,25-dihydroxy-vitamin D3 in experimental sepss"

The hormonally active form of vitamin D, 1,α25-dihydroxyvitamin D3 (1,25-vit D) is an important regulator of the calcium-phosphate homeostasis. In addition, this compound possesses a number of non-calcaemic effects. These include an effect on the immune system cell differentiation and the interaction of macrophages and monocytes and regulation of lymphocyte activity [1]. Sepsis may be complicated by a variety of conditions such as disseminated intravascular coagulation (DIC), circulatory collapse and multiple organ failure. DIC is characterized by simultaneous micro thrombo-sis and expenditure of clotting factors causing increased bleeding tendency and organ failure. Monocytes play an important role in the induction of tis-suefactor expression [2], which is seen as a key event in the development of DIC in septic patients. Therefore, there is reason to expect that 1,25-vit D could be