Tài liệu Báo cáo y học: "Characterization of erythrovirus B19 genomes isolated in liver tissues from patients

Erythrovirus (formally parvovirus) B19 (B19) causes a wide range of diseases in humans. B19 is a currently the only accepted member of the Erythrovirus genus and the only erythrovirus known to be pathogenic in humans. Several workers reported cases of children with fulminant or acute hepatitis with acute B19 infection and suggested that B19 could be the cause of the hepatitis [1-3]. Their diagnosis was based on the detection of the serum B19 DNA by PCR assay. However, the cause of fulminant hepatitis and biliary atresia in many patients is unexplained and this is a serious issue, especially in newborns and infants. More than 80% of these cases ultimately require liver transplantation or die of hepatic failure. B19 has been proposed as the cause of the fulminant hepatic failure in patients with or without aplastic anemia, on the basis of the presence of B19 DNA in liver specimens. However, the mechanism of liver damage by B19 infection remains conjectural.