Tài liệu Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"

Neurofibrillary tangles (NFT) are the cardinal intracellular lesion of Alzheimer disease (AD), and are also found in normal aging, albeit to a lesser extent. Highly phosphorylated tau protein is considered the predominant proteinaceous component of NFT [1],however, numerous other proteins have also been localized to these lesions including neurofilaments [2],ubiquitin [3, 4], amyloid-β [5], and cell cycle markers [6-11]. Notably, NFT associated with normal aging are viewed as being quantitatively different, but qualitatively identical [12]. Whether the mechanisms responsible for the genesis of NFT in AD are similar or different from the genesis of NFT in normal aging is unknown.