Tài liệu Báo cáo y học: "Association between regulated upon activation, normal T cells expressed and secreted

Asthma is a chronic inflammatory disorder of the airways and is characterized by variable airflow obstruction and bronchial hyper responsiveness (BHR) [1]. The prevalence and severity of asthma have been increasing in many countries, the trends being most pronounced for children and adolescents [2]. The pathogenesis and etiology of asthma is very complex and not fully understood, although an interaction of multiple genetic loci and a variety of en-vironmental factors have been suggested as impor-tant determinants of this disease [3,4]. It was reported that asthma is a disease with a strong genetic predis-position, and the recent increase in asthma cases seems to be triggered by increases in environmental