Tài liệu Báo cáo y học: "A Voxel-based Morphometric Analysis of Cerebral Gray Matter in Subcortical Ischemic

Vascular dementia (VD) is the third most common cause of dementia (8 to 10%), following Alzheimer's disease (AD) (60 to 70%) and dementia with Lewy bodies (DLB) (10 to 25%), but these numbers vary considerably according to the different criteria used for VaD [1,2]. Subcortical ischemic vascular de-mentia (SIVD) is an important subtype of them caused by the cerebral vessels factors (ischemia, hypoxia, etc.) which lead to brain tissue damage. It is characterized by lacunar infarcts and deep white matter changes and affects the inner parts of the brain consisting of deep white matter made up of nerve cell fibers. The term “Binswagner’s disease” is used when such de-myelination is widespread. The syndromes consist of loss of memory, judgment, reasoning, and changes in mood, behavior and communication abilities [3]. The proportion of vascular dementia (VaD) attributed to SIVD ranges from 36 to 50%, with higher rates in Af-rican Americans and Asian Americans [4] than whites [5,6].