Sách Analysis and Purification Methods in Combinatorial Chemistry

CONTENTS

PREFACE ix

CONTRIBUTORS xi

PART I ANALYSIS FOR FEASIBILITY AND

OPTIMIZATION OF LIBRARY SYNTHESIS 1

CHAPTER 1 QUANTITATIVE ANALYSIS IN

ORGANIC SYNTHESIS WITH NMR

SPECTROSCOPY 3

Laura H. Lucas and Cynthia K. Larive

CHAPTER 2

19

F GEL-PHASE NMR

SPECTROSCOPY FOR REACTION

MONITORING AND QUANTIFICATION

OF RESIN LOADING 37

Joseph M. Salvino

CHAPTER 3 THE APPLICATION OF SINGLE-BEAD

FTIR AND COLOR TEST FOR REACTION

MONITORING AND BUILDING BLOCK

VALIDATION IN COMBINATORIAL

LIBRARY SYNTHESIS 53

Jason J. Cournoyer, Clinton A. Krueger, Janice V. Wade,

and Bing Yan

CHAPTER 4 HR-MAS NMR ANALYSIS OF

COMPOUNDS ATTACHED TO

POLYMER SUPPORTS 71

Meritxell Guinó and Yolanda R. de Miguel

CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME

MONITORING AND OPTIMIZATION OF

COMBINATORIAL MATERIALS AND

PROCESS CONDITIONS 87

Radislav A. Potyrailo, Ronald J. Wroczynski,

John P. Lemmon, William P. Flanagan,

and Oltea P. Siclovan

CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE

POLYMERIC SUPPORT 125

Christine Enjalbal, Frederic Lamaty, Jean Martinez,

and Jean-Louis Aubagnac

PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY

QUALITY CONTROL 137

CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES

FOR COMBINATORIAL CHEMICAL

LIBRARY ANALYSIS 139

Ting Hou and Daniel Raftery

CHAPTER 8 MICELLAR ELECTROKINETIC

CHROMATOGRAPHY AS A TOOL FOR

COMBINATORIAL CHEMISTRY ANALYSIS:

THEORY AND APPLICATIONS 175

Peter J. Simms

CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL

ENCODED COMBINATORIAL

LIBRARIES 209

Jing Jim Zhang and William L. Fitch

PART III HIGH-THROUGHPUT PURIFICATION TO

IMPROVE LIBRARY QUALITY 253

CHAPTER 10 STRATEGIES AND METHODS FOR

PURIFYING ORGANIC COMPOUNDS

AND COMBINATORIAL LIBRARIES 255

CHAPTER 11 HIGH-THROUGHPUT PURIFICATION:

TRIAGE AND OPTIMIZATION 281

Jill Hochlowski

CHAPTER 12 PARALLEL HPLC IN HIGH-

THROUGHPUT ANALYSIS AND

PURIFICATION 307

Ralf God and Holger Gumm

PART IV ANALYSIS FOR COMPOUND STABILITY AND

DRUGABILITY 321

CHAPTER 13 ORGANIC COMPOUND STABILITY

IN LARGE, DIVERSE PHARMACEUTICAL

SCREENING COLLECTION 323

Kenneth L. Morand and Xueheng Cheng

CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN

BIOMOLECULAR RECOGNITION 351

Ming-Chung Tseng, I-Nan Chang, and Yen-Ho Chu

CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICAL

PROFILING: POTENTIAL AND

LIMITATIONS 369

Bernard Faller

CHAPTER 16 SOLUBILITY IN THE DESIGN OF

COMBINATORIAL LIBRARIES 407

Christopher Lipinski

CHAPTER 17 HIGH-THROUGHPUT DETERMINATION

Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt Jr.,

and James J. Bao

INDEX 457

OF LOGDVALUES BY LC/MS METHOD 435